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served to assess phenotypes of OGT or OGA deficiencies with out developmental deficits or compensatory adaptations. To this point, reports are still restricted to accumulating phenotypes and hypothesis producing identification of O-GlcNAc targets.Just like the studies of OGT purpose, OGA deficiency also causes pathologies in Virtually each of the t

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mTOR kinase is often a crucial molecule from the induction of autophagy. The Akt signaling pathway can activate mTOR to inhibit autophagy. Cepharanthine can induce autophagy and apoptosis in cancer cells by regulating the Akt/mTOR or AMPK/mTOR signaling pathways [forty two]. mTOR kinase can inhibit autophagy and apoptosis, and AKT can induce altera

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